The analysis of drug levels in biological
fluids is an important part of pre-clinical
and clinical trials. Sample preparation by
protein precipitation is routinely used for
the removal of proteins contained in
biological fluids, usually plasma, prior to
bioanalysis by LCMS/MS.
Protein precipitation is a generic technique
applicable to a wide variety of drug types
and is the method of choice when other
methods e.g. Solid-Phase Extraction, seem
too complex or time consuming to develop
or perform. The development of mass
spectrometry has enabled this technology
to become a standard technique.
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