As the bio-pharmaceutical industry matures, terms like ‘cost of goods’ are becoming more and more important. Up to now, strain optimisation for high productivity and upstream purificati...
The quantification of candidate pharmaceuticals and/or their metabolites in biological fluids plays a key role in drug discovery. The information generated is used to determine key pharmacokinetics...
Preparation of Calibration Standards It is normal to make up a master standard, and then prepare a series of dilutions to cover the required calibration range. Care must be taken here. Any mistakes...
Report on the 57th ASMS Conference, Philadelphia, Pa, USA May 31st - June 4th and the 18th IMSC, Bremen, Germany, September 1st - 4th 2009. Once every 3 years both of the major meetings aimed at t...
This article discusses factors important to operating a fast (high throughput) and efficient HPLC/SFC method development and prep purification laboratory. Discussion will include procedures for qu...
Vitamins are biologically active compounds required for an organism’s normal health and growth. While the required dose of vitamins is typically obtained through a balanced diet, additional...
Determination of Impurities and Related Substances Using Newly Developed 2.6 μm Core-Shell Kinetex™ LC Columns Presently, HPLC methods for the determination of impurities and related su...
Once again the 5th in the series known as ?Big Prep?, the highly successful and well respected symposium on the subject of Preparative Chromatography, will be held at the GlaxoSmithKline Medicines...
One of the least publicised areas of separation science is that of the application to clinical biochemistry. Many practitioners are based either in academia, or in hospitals yet the degree of know...
Headspace sampling is an established technique for quantitation of volatile organic compounds in various types of samples. Since only gas phase material is injected into the GC-MS, static heads...
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