Chromatography

The Need for Specific Detectors in Nitrosamine Testing in Water

Oct 31 2012

Author: Dr Mark Landon, Andrew James and Phillip James on behalf of Ellutia Chromatography Solutions

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Nitrosamines are a group of compounds pertaining to the generalised formula R1N(-R2)-N=O where R1 and R2 can be a vast array of hydrocarbon based
compounds, with over 300 known and investigated. Of these, at least 90% are known or thought to be carcinogenic, with n-nitrosodimethylamine
(NDMA) the most widely investigated and thought to be the most dangerous to health. Nitrosamines are formed in a wide range of industrial processes,
food and beverage production, as well as formation within the human stomach. Although many different mechanisms for the production of these
compounds are known, generally heat combined with an amine and a nitrate/nitrite source is the most common.

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