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May 2023 eBulletin 
How to choose the optimum IP-RP conditions for analysis of denatured or non-d... 
Small interfering RNAs (siRNAs) usually occur as oligonucleotide duplexes. They can be analysed under nondenaturing conditions so that duplex formation is assured and excessive single-strands are detected. Alternatively, analysis of siRNAs can be conducted under denaturing conditions so...
FlexiTube™ HPLC tubing Reduces Band Broadening 
Save space and maintain good chromatography when distance is required between your HPLC components or columns. FlexiTubes™ are high concentricity PEEK tubing that is coiled and will expand and contract like an old fashion phone cord; saving space and allowing distance without causing...
The secrets of glass column packing 
In order to get homogenously packed column beds, an optimised packing method is required. The most common packing method is slurry packing. In contrast to silica based packing materials, BioLC chromatography resins with polymer-based particles need additional steps and considerations du...
Retention Modeling: Simplifying & Accelerating Method Development for Small a... 
Retention modeling has proven to be a successful technique in accelerating method development and optimization. Scientists at Merck are implementing a dual strategy combining their column screening platform with in silico retention modeling to simplify and accelerate their method develo...
Introducing FLOM, Now a Part of GL Sciences 
Recently FLOM has joined the esteemed GL Sciences Group, expanding our capabilities in pumps, valves, and degassers. Founded in 1990, FLOM has become a specialist in these fields, with their factory in Japan overseeing development, assembly, and quality control. This strategic collabora...
A Non-targeted Approach to Nitrosamine Screening down to PPB Levels 
Ellutia, a leading provider of innovative analytical solutions, has recently launched the Automated Total Nitrosamine Analyser, a cutting-edge system that allows pharmaceutical companies and their suppliers to rapidly screen samples for total nitrosamine content down to ppb levels. The...
Why You Should Attend Solutions in Science (SinS) 2023 in July 
From 4th to 6th July, specialists from around the UK will gather in Cardiff City Hall for the premier analytical conference and exhibition of 2023: Solutions in Science (SinS). An expansion of the Royal Society of Chemistry’s Special Interest Group in partnership with the British Ma...
Using UHPLC for Peptide Analysis 
Peptide mapping is a crucial analytical technique in biopharmaceutical research and development. It involves the identification and characterisation of peptide sequences within a protein molecule, which is essential for understanding its structure, function, and potential therapeutic ap...
What Instruments are Used to Measure PFAS 
Per- and polyfluoroalkyl substances (PFAS) are a group of man-made chemicals that are widely used in various industrial and consumer products due to their unique chemical properties. However, these chemicals are persistent in the environment and have been linked to adverse health effect...
Using artificial intelligence in improving chromatography analysis 
The process of analysing chromatography data can be time-consuming, tedious, and error-prone, making it challenging to obtain accurate results consistently. This is where artificial intelligence (AI) can play a significant role in improving the chromatography analysis process. AI can...
Detection of N-nitrosamines in Pharmaceutical Products 
HPLC-APCI-MS/MS is a method that combines high-performance liquid chromatography (HPLC) with atmospheric pressure chemical ionisation mass spectrometry (APCI-MS/MS) to detect and quantify N-nitrosamines in pharmaceutical products. HPLC is a chromatographic technique that separates an...
Business Award recognises Outstanding Achievement 
German laboratory instrument manufacturer KNAUER Wissenschaftliche Geräte GmbH, has been honoured to receive the VORSPRUNG Business Award for the Berlin region during a ceremony at the city's Federal Chancellery on May 9. Patron Carsten Schneider, Minister of State and Federal Gove...
3D Printing Opens New Possibilities in Producing Chromatography Columns 
Over the past few years, 3D printing has revolutionised the manufacturing industry by allowing the creation of complex structures with unprecedented precision and speed. In recent times, this technology has found its way into the world of chromatography columns. A traditional chromatogr...
Instruments Used for Pesticide Analysis in Food .jpg)
One of the most commonly used analytical instruments for testing pesticides in food is Gas Chromatography-Mass Spectrometry (GC-MS). This technique separates and identifies different chemical compounds in a sample. GC-MS is highly sensitive and can detect pesticides at low concentration...
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