Laboratory Products

  • How to Prevent your Cake from Collapsing in Freeze Dried Products

How to Prevent your Cake from Collapsing in Freeze Dried Products

May 17 2019 Read 228 Times

Freeze drying is a crucial process for a variety of industries, especially pharmaceutical and biotech as it extends the shelf-life of products and makes the material safer and more convenient for transportation.

Many drugs are unstable in solution and degrade rapidly over time, therefore they must be freeze dried to produce a suitable stable product which can be shipped and has an acceptable shelf-life for storage. The freeze dried product can be reconstituted to produce a solution containing the drug ready for administration. Different drugs can be stabilised by freeze drying, these include small molecules but also biological treatments such as vaccines, proteins, enzymes, and other larger molecules.

Freeze drying API/ drug products comes with its own unique challenges and stability issues which need to be overcome. Many biological drug products require additional excipients to stabilise them during the freeze drying process and during storage.

These excipients typically stabilise the drug molecules by entrapping protein molecules in an amorphous matrix which reduces the mobility of the molecule slowing its degradation, and also by supporting the structure of the molecule when freeze dried by replacing the hydrogen bonds interactions of water, which maintain the structure of the molecule in solution, allowing its structure to be maintained once the water has been removed. The resulting product is commonly a freeze dried ‘cake’.

The freeze drying process to produce a ‘cake’ can be broken down into three main stages; freezing, primary drying and secondary drying.

In order to achieve a successfully freeze dried product, the optimised formula which gives you the best results needs to be developed. Biopharma Group can provide you support throughout the formulation development process including your pre-formulation study. With in-house equipment and expertise, Biopharma can perform DSC analysis, freeze drying microscopy (FDM), critical event frozen state analysis, MicroPress cake robustness analysis and much more.

More information online: https://ilmt.co/PL/R4xO

or visit www.biopharma.co.uk

Reader comments

Do you like or dislike what you have read? Why not post a comment to tell others / the manufacturer and our Editor what you think. To leave comments please complete the form below. Providing the content is approved, your comment will be on screen in less than 24 hours. Leaving comments on product information and articles can assist with future editorial and article content. Post questions, thoughts or simply whether you like the content.

Post a Comment




Digital Edition

International Labmate July 2019

July 2019

In This Edition Mass Spectrometry & Spectroscopy - 67th ASMS Conference on Mass Spectrometry and Allied Topics - Modular MS Bench System with Integrated Gas Supply for Sciex LC-MS/MS Unveile...

View all digital editions

Events

AACC Annual Meeting & Clinical Lab Expo

Aug 04 2019 Anaheim, CA, USA

M&M 2019

Aug 04 2019 Portland, OR, USA

DXC 2019

Aug 05 2019 Lombard, IL, USA

ACS National Meeting & Expo, Fall 2019

Aug 25 2019 San Diego, CA, USA

Microscopy Conference 2019

Sep 01 2019 Berlin, Germany

View all events