Laboratory Products

How the Adaptability of Liposomes Assists in Overcoming Today’s Drug Delivery Challenges

Aug 15 2017 Comments 0

A challenge during modern drug development is overcoming low bioavailability. Recent investigations indicate liposomes demonstrable potential to be used as a drug carrier to solve this issue.

The study of liposome-drug encapsulation is an expanding field due to their versatility and ease of manipulation in terms of their physiochemical and biophysical properties. Conventional liposomes (representation A) are composed of a lipid bi-layer and liquid core, allowing them to encapsulate hydrophilic and hydrophobic drugs. An example hydrophobic drug is Paclitaxel: a chemotherapeutic agent used to treat cancers.

Figure 1: Different types of liposomal delivery systems [2]

These types of liposomes are relatively stable at physiological pH, though their contents release under acidic conditions. This has potential in providing targeted anti-cancer therapy, through the lower pH values observed in tumour tissue.

Many formulations of pH-sensitive liposomes are unstable in the blood; overcome by adding poly-ethylene glycol lipid derivatives to the formulation, to produce PEGylated liposomes/ stealth liposomes (representation B).

Ligand-targeted liposomes (illustration C) offer potential for targeted drug delivery, by selectively expressing specific ligands at the site of disease.

Theranostic liposome systems (representation D) encapsulate a nanosized agent, such as iron-oxide and gold nanoparticles, which is utilised for imaging. Theranostic liposomes can be PEGylated and ligand-targeted to produce a comprehensive diagnostic and therapeutic drug delivery system.

Overall, adaptability is the key advantage associated with liposomes for drug delivery.

In preparation of the desired liposomes, high pressure homogenisation (HPH), is often performed on pre-formed liposomes to produce small unilamellar vesicles.

HPH also has the capability to load liposomes with drugs, allowing for a streamlined process.

Avestin’s range of high pressure homogenisers allow for the combination of homogenisation and extrusion which can reduce the number of cycles required to achieve a desired size distribution, making the process more efficient.

Read the full article by Biopharma Group here

Read comments0

Do you like or dislike what you have read? Why not post a comment to tell others / the manufacturer and our Editor what you think. To leave comments please complete the form below. Providing the content is approved, your comment will be on screen in less than 24 hours. Leaving comments on product information and articles can assist with future editorial and article content. Post questions, thoughts or simply whether you like the content.


Digital Edition

Labmate UK & Ireland October / November 2017

November 2017

In this Issue Articles - How to Achieve Ultimate PCR Optimisation Spotlight Features - Incubators, Freezers & Cooling Equipment - Balances & Strain Gauges - Proteomics, Genomics & Mic...

View all digital editions

Events

PEFTEC 2017

Nov 29 2017 Antwerp, Belgium

Saudi International Lab Expo

Dec 04 2017 Riyadh, Saudi Arabia

NepalLab

Dec 14 2017 Katmandu, Nepal

MSACL 2018 US

Jan 21 2018 Palm Springs, CA, USA

View all events