New Product Range Rapidly Removes Matrix Interferences from Urine
Feb 14 2018 Read 784 Times
Biotage, a leading global supplier of solutions and technology for analytical, medicinal and peptide chemistry, is pleased to announce the launch of ISOLUTE® HYDRO DME+ fixed well plates and columns, for the efficient removal of matrix components from urine, using a simple pass through workflow.
The novel (patent pending) dual mode extraction (DME) methodology has been developed by Biotage to provide more effective removal of matrix components such as salts, creatinine, urea, pigments and residual hydrolysis enzymes from urine using a combination of liquid partitioning and scavenging modes. Compared to the dilute and shoot approach, analyte sensitivity is increased, and instrument sensitivity is maintained over multiple injections, improving assay robustness and reducing costly downtime. The inclusion of Biotage® HYDRO frit technology means that urine samples can be hydrolysed in-situ in the well or column, eliminating the need for a post hydrolysis sample transfer step.
ISOLUTE® HYDRO DME+ products can be processed using 96-well compatible positive pressure manifolds (e.g. Biotage® PRESSURE+ 96/48), vacuum manifolds (e.g. VacMaster™-96/-10-20) and automated sample extraction systems (e.g. Biotage® Extrahera). Raw urine samples of up to 200 µL can be cleaned up using the 400 mg 96-well plate and column formats.
“ISOLUTE® HYDRO DME+ is an ideal urine clean-up product, for the simple, rapid and cost effective purification of urine matrices prior to LC-MS/MS analysis. Extracts are cleaner, meaning analytical column lifetime is extended, MS downtime is reduced and sensitivity maintained for longer,” said Dr Claire Desbrow, Global Product Manager, Analytical Chemistry, Biotage.
Do you like or dislike what you have read? Why not post a comment to tell others / the manufacturer and our Editor what you think. To leave comments please complete the form below. Providing the content is approved, your comment will be on screen in less than 24 hours. Leaving comments on product information and articles can assist with future editorial and article content. Post questions, thoughts or simply whether you like the content.
In This Edition Chromatography - Vacuum Ultraviolet Spectroscopy: A Versatile Tool for Analysis of Gasoline and Jet Fuels - High-performance Columns and Bulk for your Chromatography - New L...
View all digital editions
Oct 22 2019 Cologne, Germany
Oct 22 2019 New York, USA
Oct 23 2019 Beijing, China
Oct 30 2019 Birmingham, UK
Nov 03 2019 Toronto, Canada