Laboratory Products

  • New Distributor of Cryopreserved Terminally Differentiated Human Hepatic Cells

New Distributor of Cryopreserved Terminally Differentiated Human Hepatic Cells

Jan 10 2012 Read 1554 Times

Merck Millipore recently announced that the company will be the initial distributor of HepaRG(TM) human hepatic cells from Biopredic. HepaRG cells, derived from a hepatocellular carcinoma, are supplied as cryopreserved, terminally differentiated cells and express major liver specific functions including Cytochrome P450 enzymes and drug transporters. HepaRG cells provide a number of advantages over primary hepatocytes and liver slices for
characterisation of the uptake, metabolism, and disposition of drug candidates, drug discovery, and high throughput screening. The supply of primary cells and tissue can be unpredictable and other transformed lines such as HepG2 have not gained widespread use due to loss of specific liver functions such as Cytochrome P450, thus impacting the proper assessment of toxicity.

“With more than 900 drugs having been implicated in causing liver injury and toxicity, there is a need for more accurate prediction of hepatic cytotoxicity and genotoxicity in humans,” noted Umesh A. Patel, PhD, Director, Lead Discovery. “While in vitro human liver preparations offer the most pertinent models, availability and inter-donor variability are significant drawbacks. In contrast, HepaRG(TM) cells reproducibly express the activities drug metabolising enzymes and transporters to facilitate ADME/tox studies.”

Reader comments

Do you like or dislike what you have read? Why not post a comment to tell others / the manufacturer and our Editor what you think. To leave comments please complete the form below. Providing the content is approved, your comment will be on screen in less than 24 hours. Leaving comments on product information and articles can assist with future editorial and article content. Post questions, thoughts or simply whether you like the content.

Post a Comment

Digital Edition

Labmate UK & Ireland September 2019

September 2019

Articles Finding an easy, cost-effective way to break into new markets Exploring safe and intelligent multi-application liquid nitrogen cooling via auto-fill technology Characterisation o...

View all digital editions


Analytica Anacon India & IndiaLabExpo

Sep 19 2019 Hyderabad, India

16th Confocal Raman Imaging Symposium

Sep 23 2019 Ulm Germany

Analitica Latin America

Sep 24 2019 Sao Paulo, Brazil

Pharma Asia

Sep 24 2019 Karachi, Pakistan


Sep 24 2019 Basel, Switzerland

View all events