• Facile LC-MS/MS Analysis of sphingolipids Using Metal-free Column

LC-MS

Facile LC-MS/MS Analysis of sphingolipids Using Metal-free Column

Jun 26 2019

In LC analyses of sphingophospholipids, such as sphingosine-1-phosphate(S1P) and ceramide-1-phosphate (C1P), a phosphate group in these molecules causes significant peak tailing, and therefore loss of sensitivity and reproducibility.

Recently, an improved LC-MS/MS method using a YMC-Triart C18 column in metal-free hardware was published by Gowda et al in the "Analytical and Bioanalytical Chemistry" journal. This application note shows the improved method using a YMC-Triart C18 metal-free column in comparison with the method using a conventional C18 column.


Digital Edition

Chromatography Today - Buyers' Guide 2022

October 2023

In This Edition Modern & Practical Applications - Accelerating ADC Development with Mass Spectrometry - Implementing High-Resolution Ion Mobility into Peptide Mapping Workflows Chromatogr...

View all digital editions

Events

analytica 2024

Apr 09 2024 Munich, Germany

Korea Lab 2024

Apr 23 2024 Kintex, South Korea

Korea Chem 2024

Apr 23 2024 Seoul, South Korea

AOCS Annual Meeting & Expo

Apr 28 2024 Montreal, Quebec, Canada

SETAC Europe

May 05 2024 Seville, Spain

View all events