Mass Spectrometry & Spectroscopy

  • Mass Spectrometer System Offers Solution for Small Molecule Identification and Characterisation

Mass Spectrometer System Offers Solution for Small Molecule Identification and Characterisation

Jul 05 2018 Read 252 Times

The Thermo Scientific Orbitrap ID-X Tribrid Mass Spectrometry system combines quadrupole, Orbitrap and linear ion trap mass analyser technology, novel automated data acquisition strategies, and powerful structural analysis software to significantly improve small molecule compound identification.

“Interpreting an unknown compound’s mass spectra continues to be a considerable challenge and a bottleneck to progress in many important fields of study,” said Evett Kruka, Vice President and General Manager, life sciences mass spectrometry, Thermo Fisher. “With the launch of the Orbitrap ID-X Tribrid Mass Spectrometry system, and its associated data acquisition and analysis software tools, customers now have access to a complete, intelligent and automated solution that can accelerate and transform small molecule identification and characterisation.”

“The Orbitrap ID-X Tribrid mass spectrometer delivers complementary information with multiple dissociation techniques and robust MSn data required to deduce structural information and increase confidence in metabolite annotation,” said Warwick Dunn, PhD, professor, Analytical and Clinical Metabolomics at the Phenome Centre Birmingham, School of Biosciences and Institute of Metabolism and Systems Research, University of Birmingham, UK. “With AcquireX built-in intelligent data acquisition, we now collect more informative data and, not just more data, we can maximise metabolome coverage and increase confidence in the identification on unknowns applying intelligent-DDA approaches.”

Designed as a complete solution from data acquisition to data analysis, the Orbitrap ID-X Tribrid Mass Spectrometry system offers the following benefits: Proven and trusted Tribrid architecture combined with fit-for-purpose user interface designed to efficiently acquire high-quality data using ready-to-use experimental parameters; AcquireX, a fully automated acquisition workflow allowing for comprehensive sample interrogation capturing critical data; MSn library-generating tool allows users to create their own spectral library for subsequent data analysis; m/z Logic, an automated MSn data processing routine designed for improved coverage with increased confidence.

The seamless combination of the Orbitrap ID-X Tribrid Mass Spectrometer with software acquisition and analysis solutions, including Thermo Scientific Mass Frontier 8.0 spectral interpretation software and Thermo Scientific Compound Discover 3.0, facilitates the characterisation of small molecules, the elucidation of their structures, the identification of metabolites and the detection of extractables/leachables by users with a range of experience and expertise.

For more information on the Orbitrap ID-X Tribrid Mass Spectrometer, please visit www.thermofisher.com/OrbitrapID-X.

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