Mass Spectrometry & Spectroscopy

  • New-Generation Benchtop Mass Spectrometer Advances Quantitative Proteomics and Translational Research

New-Generation Benchtop Mass Spectrometer Advances Quantitative Proteomics and Translational Research

Aug 05 2019 Read 520 Times

The Thermo Scientific™ Orbitrap™ Exploris 480 mass spectrometer unlocks the power of an advanced differential ion mobility interface option and internal standard-triggered methods. It is designed for advanced protein analysis, quantitative proteomics and small molecule applications used in biopharmaceutical and translational research. It combines proven technology, advanced capabilities and intelligence-driven data acquisition strategies for rigorous, high-throughput protein identification, quantitation and structural characterisation of biotherapeutics and translational biomarkers.

The system provides enhanced quantitative performance across label-free and tandem mass tag (TMT) experiments, as well as access to new Thermo Scientific™ SureQuant methods for ultra-sensitive targeted protein assays. This combination allows researchers to conduct rapid, multiplexed analysis of proteins within complex biological matrices. With a smaller footprint than previous generations, the new system maximises laboratory bench space while maintaining high-resolution, mass accuracy and spectral quality.

Additionally, the Orbitrap™ Exploris 480 MS has many new features to extend uptime and improve serviceability for researchers in high-throughput laboratory environments.

Users of the Orbitrap™ Exploris 480 will experience the immediate convenience and benefits of a common method programming interface and sources, shared with Thermo Scientific™ Tribrid and Triple-stage Quadrupole (TSQ) instruments. The Orbitrap™ Exploris 480 MS takes full advantage of the Thermo Scientific™ FAIMS Pro Interface, which can boost the already-extensive proteome coverage of the instrument by 20 percent.

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