New System Reflects Growing Importance of Impaction Force in Characterising Pharmaceutical Sprays
May 03 2007
Recent work by the FDA highlights the application of spray impaction force for in vitro equivalence studies, and raises the possibility of using maximum force measurements at different distances from the mouthpiece for quality control purposes. Of all the variables that can be used to characterise a spray, impaction force is the one most noticeable to the patient and is also closely correlated with aerosol deposition behaviour.
The SFT1000's highly sensitive load cell permits accurate measurement of maximum impaction force (+/- 2.5 mN) during the spray event. The distance between the test device and impaction plate can be simply set and/or varied using the precision slide rails with integral lock, and the impaction plate is easily removed for cleaning. The unit can be operated either vertically or horizontally for the representative testing of nasal sprays or metered dose inhalers respectively and the calibration can be easily verified, in the lab, by the user.
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