Analysis of Volatile Compounds by GC-Headspace



Date: 15:00:00 - Mar 15 2018
Speakers: Neal Fox, Sandra Lorenz
Moderators: Tom Lynch CChem FRSC

This eLearning session is for anyone analyzing residual solvents or interested in quantitative GC-Headspace analyses.        

GC-Headspace is a powerful technique for the analysis of volatile compounds in neat samples or in a variety of matrices. A major use of GC-Headspace is the analysis of pharmaceutical drugs, as well as intermediates and excipients for the presence of residual solvents that may be left over from the manufacturing process. The sample that is analyzed by this technique may be a solid, a solid dissolved in a solvent, a liquid, or a matrix such as soil for environmental analysis. During this webinar, we will review the method development that was done to apply this technique to solvents, particularly higher boiling solvents that are ideal for GC Headspace.

Learning objectives

By attending this webinar you will learn:

  • How GC-Headspace works along with some tips and tricks for test method optimization
  • Criteria to determine if GC-Headspace is a good technique for a given analysis
  • Applications where GC-Headspace is ideal
  • The residual solvents technique used in analysis of pharmaceuticals (final drug, intermediate, excipients)
  • Honeywell brands and products that are tested and certified for use in GC-Headspace applications

You will have an opportunity to ask Sandra and Neal any questions about GC-Headspace, or find out a little more about Honeywell Research Chemicals – a large producer of solvents and reagents under the Riedel-de Haën™, Burdick & Jackson™, and Fluka™ brands.

Watch this session

This is a free OnDemand session

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Neal Fox
Neal Fox (Honeywell)

Neal Fox started working at Honeywell in 2000 as an Analyst in the QC department. He moved on to fill the QC Supervisor role, and now serves as a Process Chemist. Neal has been involved in the Western MI section of the ACS, serving as local section chair and then as the alternate councilor. While serving as alternate councilor to the local section, Neal was also leading an effort to host a regional ACS meeting as General Chair of the Joint Great Lakes / Central Regional Meeting of the ACS in 2015. He then went on to serve as Chair of the Central Region of ACS (2015-2016).

Sandra Lorenz
Sandra Lorenz (Honeywell)

Sandra Lorenz received her master’s degree in physical chemistry at Iowa State University in 1992. She attended Hope College for her undergraduate degree. Sandra has worked in various chemical operations over her career. She has spent the last 13 years working in R&D and technical service at Honeywell. She has expertise in the area of high purity solvents and oligonucleotide synthesis reagents. Sandra is a contributing author on 2 granted patents in the area of utilization/production of high purity solvents.


Tom Lynch CChem FRSC
Tom Lynch CChem FRSC (International Labmate Ltd)

Tom has 35 years’ of experience in the petroleum industry, specialising in the delivery of forensic and problem solving /method development capabilities for BP Fuels and Lubricants businesses globally. He was also a member of the BP Science Council representing Analytical Science and led a BP wide Analytical Science network. Tom has published over 30 citable papers, 4 book chapters and has given over 60 presentations at conferences. He is a past Vice President of the Royal Society of Chemistry (RSC) Analytical Division and a past Chairman of the RSC Separation Science Group. In addition, Tom is a recipient of the Silver Jubilee Medal by the Chromatographic Society and a technical achievement award by the Energy Institute.

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