• Predicting the Release of APIs by Near-Infrared Spectroscopy

Infrared / IR

Predicting the Release of APIs by Near-Infrared Spectroscopy

Oct 20 2014

Sustained-release formulations that gradually release active pharmaceutical ingredients (APIs) have numerous therapeutic benefits, but they also involve time-consuming quality control. Near-infrared spectroscopy (NIRS) offers a fast and simple alternative to tedious dissolution testing: by using NIRS and appropriate calibration models, the release of APIs from sustained-release tablets can be predicted accurately within a matter of minutes. More details are available from a recently published paper.

Drug release is still frequently assessed by dissolution tests, a procedure, in which the tablet is placed in a solvent with similar properties to gastric acid. The free active ingredient is then determined at regular intervals, which can take up to 24 hours, depending on the desired release period.

NIRS offers a viable alternative to dissolution testing. By using NIRS together with an appropriate calibration model, it is possible to predict the dissolution behaviour of tablets accurately in a matter of minutes. Moreover, NIRS, unlike dissolution testing, is non-destructive, which allows larger sample quantities to be analysed.

Digital Edition

Lab Asia 31.2 April 2024

April 2024

In This Edition Chromatography Articles - Approaches to troubleshooting an SPE method for the analysis of oligonucleotides (pt i) - High-precision liquid flow processes demand full fluidic c...

View all digital editions



May 28 2024 Tel Aviv, Israel


May 28 2024 Leuven, Belgium

PREP 2024

May 28 2024 Philadelphia, PA, USA


May 29 2024 Beijing, China

ASMS Conference

Jun 02 2024 Anaheim, CA, USA

View all events