A Dedicated Workspace for Oligonucleotide Characterisation

Shimadzu released LabSolutions Insight Biologics, an advanced software solution designed for the comprehensive characterisation of oligonucleotides.

This innovative tool automates the process of oligonucleotides characterisation. Enabling first time users to identify sequences and impurities in a few simple steps. The interface provides an easy method to input sequence information, configure target modifications, and set data analysis parameters

Insight Biologics utilises the Nexera BioInert LC and LCMS-Q-TOF with Data Dependent Acquisition (DDA) to provide MS/MS spectra with detailed base-by-base sequence information, site-specific modifications, and sequence mapping. All contributing to the confirmation of products and identification on unknowns.

The software automatically conducts a thorough search for principal components and impurities from MS and MS/MS spectra, drastically reducing characterisation time by 90% compared to conventional methods. Visual displays of sequence coverage bolster confidence in identifications. The seamless processing and reporting capabilities, coupled with audit trail support, make Insight Biologics a comprehensive and efficient solution for oligonucleotide characterisation.

This cutting-edge software is developed to seamlessly integrate with Shimadzu's Nexera BioInert LC coupled with the LCMS-9030 or LCMS-9050 quadrupole time-of-flight type (Q-TOF) mass spectrometers, offering a dedicated workspace for oligonucleotide analysis.

Find out more here.