• Automated parallel capillary electrophoresis system simplifies protein analysis

Laboratory Products

Automated parallel capillary electrophoresis system simplifies protein analysis

Apr 22 2024

The Agilent ProteoAnalyzer system is an automated parallel capillary electrophoresis system for protein analysis. This innovative platform simplifies and enhances the efficiency of analysing complex protein mixtures, catering to diverse sectors including pharma, biotech, food analysis, and academia.

Capillary electrophoresis (CE) has become a cornerstone in protein separation due to its rapid, high-resolution analysis and minimal sample consumption. With growing interest in monoclonal antibodies and therapeutic protein targets, the demand for CE solutions is on the rise.

The ProteoAnalyzer automates capillary electrophoresis-sodium dodecyl sulfate (CE-SDS) analysis of reduced and non-reduced protein samples. Processing 12 samples in just 30 minutes, it eliminates the cumbersome SDS-PAGE gel preparation, staining/destaining, and analysis, allowing users to focus on results.

With the capability to separate proteins ranging from 10 to 240 kDa in a single run, the system accommodates diverse samples, including monoclonal antibodies, biosimilars, and crude lysates. Individual capillaries are rejuvenated between each separation, ensuring accurate analysis across various sample types.

The ProteoAnalyzer system enhances efficiency, versatility, and reliability, particularly in protein QC workflows. By automating separation, data processing, and simplifying sample preparation, it streamlines analysis workflows, reducing training and labour costs. Additionally, it can analyse different sizes and types of proteins in a single run, consistently delivering accurate results and minimising the need for reanalysis.

Knut Wintergerst, Vice President and General Manager of Agilent's Biomolecular Analysis Division, emphasises the system's efficiency, versatility, and reliability, stating that it simplifies the analysis of complex mixtures across diverse sectors, from pharma to academia.

As a market leader in CE, Agilent's ProteoAnalyzer strengthens its position as a provider of quality control analysis solutions, extending its CE portfolio across relevant biomolecule classes and catering to the evolving needs of various industries.

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