• New Cd85d (ilt4)-pe Ruo Monoclonal Antibody Identifies Tolerogenic Cells

Laboratory products

New Cd85d (ilt4)-pe Ruo Monoclonal Antibody Identifies Tolerogenic Cells

Beckman Coulter introduces IOTest® CD85d-(ILT4)-PE conjugated monoclonal antibody. ILT4 is selectively expressed on myelomonocytic cells and binds to classical and nonclassical human leucocyte antigen (HLA) class I molecules. ILT4 is believed to play a number of roles in cellular function, including the modulation of APC functions (e.g. antigen uptake, migration and cytokine production), control of inflammatory response and maternal tolerance against the foetal semi-allograft. CD85d-PE is offered exclusively by Beckman Coulter and completes the company's list of clones against immunoglobulin (Ig)-like transcripts.

The new CD85d-PE antibody is useful in basic research on leucocyte function, dendritic cells, immunosuppression, tolerogenicity and maternofoetal tolerance. Its ability to identify tolerogenic cells makes the new antibody particularly valuable for transplant and cancer research. It is also applicable in clinical research on autoimmunity. CD85d-PE delivers advantages over other antibodies in applications where control of tolerogenicity is important.

"We are excited to increase our offerings in ILT markers," commented Michel Pagniez, Cellular Analysis Product Manager for Beckman Coulter. "The biology of these types of cells is critical to driving immune response."

The preformulated, standardised IOTest CD85d-PE monoclonal antibody is provided in 100-test vials. Beckman Coulter offers a number of reagents, controls and markers that can be used with this new antibody. CD85d-PE is approved for research use only.

Digital Edition

ILM 50.3 April 2025

May 2025

Chromatography Articles - Optimising two-step purification: Key considerations for sample pump setups Mass Spectrometry & Spectroscopy Articles - Detecting pharmaceuticals and their transf...

View all digital editions

Events

Future Labs Live Basel 2025

May 27 2025 Basel, Switzerland

ASMS Conference

Jun 01 2025 Baltimore, MD, USA

Chemspec Europe 2025

Jun 04 2025 Koeln, Germany

Lab & Test Asia

Jun 11 2025 Bangkok, Thailand

HPLC 2025

Jun 15 2025 Bruges, Belgium

View all events