New Monoclonal Antibody for Cyclin A2 Identification

Beckman Coulter introduces the IOTest® Anti-Cyclin A2 monoclonal antibody, for the study of cell cycle transitions in life science research. This FITC-conjugated antibody is the newest addition to Beckman Coulter's universal cytometry reagent line, which works on all instrument platforms, including the company's Cell Lab Quanta? and FC 500 MPL flow cytometers.

Cyclin A2 is important in the transition to DNA synthesis and replication phases of the cell cycle and is abruptly destroyed as the cell moves into mitosis. Cyclin A2 is present in proliferating somatic cells, and its absence indicates that the cell is no longer replicating. The expression and diminishing expression of cyclin A2 are thought to play a prominent role in tumorigenesis. The new IOTest Anti-Cyclin A2 monoclonal antibody is useful in a wide range of applications including basic research on cell cycle control, apoptosis and tumorigenesis; clinical cancer studies; and pharmaceutical discovery efforts to identify inhibitors, blockers and antimitotic drugs.