Laboratory Products

  • First IVD pan-TRK Immunohistochemistry Assay Launched

First IVD pan-TRK Immunohistochemistry Assay Launched

Nov 27 2018 Read 499 Times

Roche have announced the global launch of the VENTANA pan-TRK (EPR17341) Assay, the first automated in vitro diagnostic (IVD) immunohistochemistry (IHC) assay to detect tropomyosin receptor kinase (TRK) proteins in cancer.

With the launch, laboratories are now able to identify wild-type and chimeric fusion proteins through detection of the TRK C-terminal region. This assay can be used to perform analytic studies, including prevalence in solid tumours.

While wild-type protein expression is generally low in both prevalence and intensity level, it can be substantial in some neuroendocrine tumour tissues. TRK-fusion proteins have been identified in a wide range of commonly occurring tumours, including lung, thyroid and sarcoma, at a low frequency. In some rare tumours, including infantile fibrosarcoma, secretory and juvenile breast cancer and mammary analogue secretory cancers of the salivary glands, TRK fusion proteins are likely to be the defining genetic feature.

"As the first test of its kind, the VENTANA pan-TRK (EPR17341) Assay provides an important new tool to help us better understand the role of TRK protein expression, particularly fusions in cancer," said Jill German, Head of Roche Tissue Diagnostics. "We are excited to see the new information that results from the use of this important technology, and its ultimate impact for patients."

The VENTANA pan-TRK (EPR17341) Assay is available for use on Roche's BenchMark series of IHC/ISH automated staining instruments.

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