• New Proteins and Peptides Mass Spectrometer Introduced

Mass Spectrometry & Spectroscopy

New Proteins and Peptides Mass Spectrometer Introduced

Jun 15 2016

Advion, Inc have announced the introduction of a proteins and peptides analysis system, 'TIDES EXPRESS.  The system combines Advion's new, easy-to-use, HPLC system with the extended mass range expressionL compact mass spectrometer (CMS).  The new platform improves the workflow of chemists performing peptide synthesis and needing fast mass analysis of each reaction step as well as final products. It is the perfect technique for monitoring reactions in solid phase peptide synthesisers.  Additional fragmentation analysis and charge deconvolution tools also enhance its use for protein characterisation.

Solid phase peptide synthesis (SPPS) allows for rapid, parallel synthesis of peptides of various amino acid (AA) lengths, some of which routinely exceed 30 or 40 in length. Although modern SPPS shows a high degree of automation, some SPPS peptide targets remain challenging to synthesise and a single suboptimal synthesis cycle can cause costly re-runs in large scale or long chain protein production, rapid analysis of each reaction step can prevent this.  Mass spectrometry provides both molecular mass and amino acid sequence information through specific and selective molecule fragmentation along the amino acid backbone.  The 'TIDES EXPRESS includes an easy-to-use HPLC gradient system with manual sample injector, expressionL CMS along with fragmentation analysis and charge deconvolution software tools for easy and excellent data interpretation.

"The complexity of proteins and peptides analysis requires efficient and cost-effective analysis for informed decision making," said Simon Prosser, Vice President of Marketing.  "The ease-of-use and compact size makes the 'TIDES EXPRESS ideal for bench-top reaction monitoring of SPPS systems, most of which to-date have been limited to UV or IR monitoring of analytes."


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