• GHIT Grant to Advance Neglected Disease Drug Discovery

News

GHIT Grant to Advance Neglected Disease Drug Discovery

The University of Liverpool’s Department of Chemistry and the Liverpool School of Tropical Medicine (LSTM), together with  Japanese pharmaceutical company Eisai, have been awarded a Global Health Innovative Technology (GHIT) grant which will fund the development of a new drug to target the neglected tropical diseases lymphatic filariasis (LF) and onchocerciasis, both debilitating infections affecting more than 150 million people globally.

The £3,250,000 funding for this new phase will support a series of Phase I human clinical trials, which will assess the safety of the drug in humans.

LSTM’s Deputy Director and project lead, Professor Steve Ward said “We are extremely pleased and proud to be able to continue this unique partnership between LSTM, the University of Liverpool and Eisai. Our approach of killing the parasitic worm by targeting the essential bacteria within the worm is totally unique and one that offers many advantages over drugs that target worms directly.”

Proof-of-concept clinical trials have already shown that this alternative approach works and can reduce elimination timeframes significantly from decades to years. The drug candidate also has the potential to be used in the whole population, including children and pregnant women.
AWZ1066S, provides a unique opportunity to make a large contribution to communities affected by these diseases.

This novel molecule was developed from a screening hit by several rounds of chemistry optimisation at the University’s Department of Chemistry.

Liverpool Chemist, Professor Paul O’Neill, said “ Our optimisations from a hit to preclinical candidate were achieved in under three years which underlines the success of the medicinal chemistry approaches used in this project.”

Dr David Hong, development team, added: “Receiving the financial support (award) from GHIT to enable the progression to human clinical trials is an important milestone in filariasis drug discovery.”

The GHIT Fund facilitates and funds global partnerships for the discovery and development of new health technologies, including drugs, vaccines and diagnostics, for infectious and neglected tropical diseases prevalent in developing countries.


Digital Edition

Lab Asia 32.1 Feb 2025

February 2025

Chromatography Articles - Comparing volumetric and thermal flowmeters for assessing and validating liquid chromatography performance Mass Spectrometry & Spectroscopy Articles - The importa...

View all digital editions

Events

SPS Smart Production Solutions Guangzhou

Feb 25 2025 Guanghzou, China

SmartLab Exchange

Feb 25 2025 Amsterdam, Netherlands

Nepal Lab

Feb 27 2025 Kathmandu, Nepal

PITTCON 2025

Mar 01 2025 Boston, MA, USA

IFPAC 2025

Mar 02 2025 Bethesda, MD, USA

View all events