• Wild About the Evolution of Domesticated Yeast

News & Views

Wild About the Evolution of Domesticated Yeast

Apr 29 2009

As probably one of the earliest domesticated organisms having been used by humans for tens of thousands of years for baking and brewing, yeast is today regarded by geneticists as the ‘model’ model organism, because of its genetic similarities to humans and the powerful tools currently available. However, with domesticated yeast at the forefront of major breakthroughs in genomics, researchers began to question whether the highly selected yeast produced for laboratory experiments in any way influenced the outcome of scientific research.


After five years searching for the answer a team of scientists, led by Ed Louis at The University of Nottingham and Richard Durbin a principal investigator at The Sanger Institute and  who is currently involved in the 1000 genome project, believe that even after centuries of  domestication, the yeast we tamed for science, brewing and baking is actually much the same as its closest relatives still living in the wild.


“In brief our study accomplished two things. First, the high levels of variation seen between strains of yeast required the building of bioinformatics tools which could handle multiple comparisons with such diversity within very similar genomes. These tools are now being used for similar studies in humans including for the 1000 human genome project. The fact that yeast exhibited so much variation yet its genome is less than 1/300 of the human genome in size was a prime motivation for Richard’s involvement in this project as it would provide them with a test dataset for bioinformatics tool building and analysis,” said Professor Louis


“The second finding has to do with yeast evolution itself,” continued Professor Louis. “The baker’s yeast, Saccharomyces cerevisiae, is the ‘model’ model organism because of its ease in manipulation, the powerful tools available for study and its similarities to all life in fundamental biological processes. It has, however, had a long association with humans through fermentation activities and it has been argued that yeast is domesticated to such a point that it no longer resembles its original wild ancestors.


“We sequenced over 35 strains of baker’s yeast from many locations and sources including wine, bread and sake making to wild fruit and flower fermentations to clinical and food spoilage isolates. In addition we sequenced over 35 strains of the closest wild cousin,  Saccharomyces paradoxus, which is found in similar locations but has never been used in human fermentation activities.”


“Our findings are most consistent with baker’s yeast being  natural and close in its evolution to its relatives and that rather than domesticating yeast, we have merely utilised strains with appropriate properties and moved them around the world.”


“The variation we describe not only informs us of evolutionary processes going on in these yeasts but provides us with the sequence data that will allow us to determine what makes a good baking strain versus a brewing strain as well as what makes a strain a clinical problem
in some cases. We can also use the information to improve the fermentation properties of yeast either in sugar utilisation, ethanol production or flavour enhancement. For example, we will be surveying the strains and the variation within them for improved ethanol production as part of the biofuels project in the BBSRC funded BioEnergy Centre. We can also use the variation to determine the genetic factors involved in many
complex traits, some of which model human disease,” he added. 

Dr Richard Durbin, said: "We have been able to use the amazing power of modern DNA sequencing to obtain an unprecedented picture of the way the genes in this organism vary, and how it evolved. The tools we developed to study yeast are now being applied to the human genome, to help identify genetic variants that are involved in disease.” Their research findings which has established the level of variation between different populations and species of yeast have been published in Nature.
(Yeast culture picture courtesy of BBSRC)


Digital Edition

Lab Asia 31.2 April 2024

April 2024

In This Edition Chromatography Articles - Approaches to troubleshooting an SPE method for the analysis of oligonucleotides (pt i) - High-precision liquid flow processes demand full fluidic c...

View all digital editions

Events

Lab Indonesia

Apr 24 2024 Jakarta, Indonesia

Expomed Eurasia

Apr 25 2024 Istanbul, Turkey

AOCS Annual Meeting & Expo

Apr 28 2024 Montreal, Quebec, Canada

SETAC Europe

May 05 2024 Seville, Spain

InformEx Zone at CPhl North America

May 07 2024 Pennsylvania, PA, USA

View all events