• Minimising thermal stress in molecular distillation
    Pilodist SP 1000 CC wiped-film evaporator for short-path and molecular distillation.
  • Precise temperature control with Julabo circulators is key for short-path and molecular distillation with the SP 1000 CC.

Temperature Control / Sterilising

Minimising thermal stress in molecular distillation

Mar 05 2024

Molecular distillation, also called high vacuum wiped film, thin film or short path distillation, is a well-known process to separate thermally sensitive material. Combined in a new unique construction with precise temperature control units, this allows high performance distillation for many different applications and products.

Short path and molecular distillation

The main concept of short path distillation is to prevent breakdown or cracking by minimising residence time and thus thermal stress. This is achieved by letting the product pass through a heated tube where wipers distribute the material and create a thin film for enhanced evaporation. Additionally, thermal stress is reduced by lowering the boiling point of the product (i.e. by applying vacuum).

Molecular distillation is a special form of short path distillation where the pressure is reduced even further, typically to less than 1x10-2 mbar. Through this, the mean free path of any molecule leaving the evaporator is longer than the distance between evaporator and condenser. That way all back-pressure (like in a conventional distillation column) is eliminated. Now the boiling point is no longer dependent on the vapor pressure but only on the molecular weight.

Hybrid construction for versatile and efficient distillation

The SP 1000 CC from Pilodist GmbH is a turnkey system for laboratory use and small scale production. It is optimised to cover a wide range of applications, from high melting to high boiling points and can handle thermally sensitive material with full flexibility and completely continuous operation.

For optimal results it is crucial to have precise control over vacuum and temperature. For this, the SP 1000 CC uses individual temperature control units for all heating and cooling circuits. The feed vessel, tempered with a Julabo heating circulator, can pre-heat product to tailor its viscosity for ideal flow. The evaporator is also operated with a Julabo heating circulator for optimal heat transfer with a high circulation speed while the condenser uses a Julabo refrigerated circulator to collect and cool down the distillate. In addition, the condensation trap for collecting the very light volatiles is cooled with an Julabo immersion cooler down to -90°C.

More information online

Digital Edition

Lab Asia 31.2 April 2024

April 2024

In This Edition Chromatography Articles - Approaches to troubleshooting an SPE method for the analysis of oligonucleotides (pt i) - High-precision liquid flow processes demand full fluidic c...

View all digital editions


Expomed Eurasia

Apr 25 2024 Istanbul, Turkey

AOCS Annual Meeting & Expo

Apr 28 2024 Montreal, Quebec, Canada

SETAC Europe

May 05 2024 Seville, Spain

InformEx Zone at CPhl North America

May 07 2024 Pennsylvania, PA, USA

ISHM 2024

May 14 2024 Oklahoma City, OK, USA

View all events