Multi-angle Light Scattering Detector for Accurate Molecular Measurement

Over the past four decades, light scattering has become widely used for molecular weight and size measurement of proteins and polymers. However, the most recent and ever more demanding characterisation needs require to overcome the limitations of the various traditional technologies in light scattering detection.

The Tosoh LenS3® Multi-Angle Light Scattering (MALS) detector features an elongated flow path geometry that maximises scattered light collection, while the non-refractive material of the chamber eliminates noise from stray light. The advanced optical design also provides exceptional signal-to-noise at the crucial extreme angles for molecular weight and size measurements.

The resulting enhanced capabilities and unprecedented sensitivity of the LenS3 MALS detector provide a direct and accurate measurement of molecular weight, even for oligomers and low dn/dc samples. Moreover, the range of radius of gyration (Rg) determination by light scattering is extended down to a few nanometers for the very first time.

Read Tosoh Bioscience’s latest whitepaper here

A new technical note delivers also more detailed information on the MALS detector.