GMP collagen type I additive for reinforcing bioprinted constructs

Produced using dry-spun 50 µm Collagen Type I fibres, AMSBIO has introduced the innovative CollaFibR™ additive proven to increase the shape fidelity and biological relevance of bioprinted constructs in hydrogels and bioinks.

In the field of personalised tissue engineering, 3D bioprinting shows immense promise, but the challenge lies in achieving both mechanical durability and biological relevance in the printed constructs.

Acting as a physiologically relevant site for cell attachment within constructs - μCollaFibR™ has been shown to improve the shape retention and durability of bioprinted cellular constructs for at least 28 days. Additionally, these short collagen fibres can enhance the mechanical strength and flexibility of hydrogels under both tension and compression, proving beneficial for 3D cell culture applications like organoids.

Offering exceptional chemical stability and easily suspended in aqueous media, including acidic environments, μCollaFibR™ emerges as a versatile option for bioprinting. It is universally compatible with bioprinting materials such as GelMA, alginate, gelatin, and agarose, unlocking boundless possibilities in biomedical research and clinical applications.

Manufactured using GMP compliant protocols with GMP bovine type I collagen, the quality of μCollaFibR™ is validated with a variety of cell lines including fibroblasts, myoblasts, epithelial cells, neural cells, and primary cells such as bone marrow derived MSCs.

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