Low Volume Degasser Module for Microfluidic Systems

Biotech Fluidics has developed innovative low-volume online degassing modules designed for micro- and nanofluidic systems, utilised in various life science applications such as dispensing, diagnostics, drug screening, nucleic acid sequencing, and tissue culture.

In micro- and nanofluidic systems, the emergence and accumulation of air or gas bubbles can have severe detrimental effects on their functionality. Eliminating such bubbles once they form poses significant challenges. These bubbles can trigger aggregation issues with particles or proteins, impair the chemical functionalisation of surfaces, and in the case of cell culture, result in cellular death.

Robin Oz, Degassing Product Specialist at Biotech Fluidics, commented: “We have observed how a single gas bubble in micro and nano liquid dispensers can impair their dispensing precision and accuracy. Removing dissolved gases from liquids prior to dispensing eliminates the risk of having bubbles in the fluidic channels.”

He added: “Another microscale application where liquid degassing is crucial is Surface Plasmon Resonance (SPR) analysis. The sensing mechanism in SPR is heavily based on interactions between analyte and a functionalised surface. A bubble will create an obstruction on the surface, resulting in an irregular and non-specific signal and creating an abnormality in the resulting sensogram. Installing a low volume DEGASI online degassing module prior to liquid introduction to the SPR system completely negates this gas bubble problem.”

The DEGASi® PLUS MICRO from Biotech Fluidics is an advanced degasser tailored for SPR and other micro- and nanofluidic system applications. With a low volume capacity of 100 µl per channel, this cutting-edge system effectively eliminates dissolved gases from the liquid phase, preemptively preventing the formation of bubbles. Moreover, it efficiently removes oxygen, ensuring seamless compatibility with UV detection methods. The DEGASi® PLUS MICRO is available in versions ranging from 1 to 6 channels.

To discuss how to degas your micro- or nano fluidic application please contact Biotech Fluidics.

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