Launch of a Triple Laser Microplate Cytometer for High Content Screening
May 14 2007
Scanning up to 64 whole wells at a time, the Acumen range of laser-scanning fluorescence microplate cytometers can perform cytometric analyses at throughputs of up to 200 plates - or 300,000 data points (1536 plates) - per day.
Putting the development of the AcumenÂ® eX3 in context, Wayne Bowen, TTP LabTech's CSO said; "The Acumen ExplorerÂ® is routinely relied on for high content screening in industry and academia because of its unique ability to combine data collection from whole well scanning with fast read times. The AcumenÂ® eX3 offers huge flexibility: researchers can select the optimum laser combination required to excite the fluorescent probes being used. Since nuclear staining is not required to locate the cells, all probes may be used for reporting biological responses. The upshot is that, with simultaneous four colour detection, the AcumenÂ® eX3's possible performance exceeds the limits of current multicolour, multiplexed assay protocols, giving an assurance of future-proofing."
The AcumenÂ® eX3's enhanced software gives the added flexibility of exporting TIFF images which closely match those captured using a 20x microscope objective for subsequent analysis by third party image analysis software. This facilitates the seamless transfer from assay development on microscope-based CCD Imagers to assay screening on the AcumenÂ® eX3 with minimal changes to experimental protocols. Flexibility is further assured since the AcumenÂ® eX3's functionality can be built-up over time, starting with one laser and retrospectively adding additional lasers, depending on user or assay requirements.
By combining the power of rapid, whole well data collection with the ability to classify objects within cells, or sub-cellular events, the AcumenÂ® eX3 represents a major breakthrough for microplate cytometers in the assay development-to-screening process.
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