News & Views
Role of Carrier Protein determined at CLS
Aug 11 2023
Researchers from the University of British Columbia (UBC) have identified a new protein that helps an oral bacterium thrive in other locations around the body. Most notably, this bacteria is prevalent in the tumours of colorectal cancer patients.
“This bacterium is common in the mouths of humans and generally doesn’t cause disease in that location. However, it can travel through the bloodstream to other areas of the body, which leads to some pretty big health concerns,” says Dr. Kirsten Wolthers, Associate Professor of Biochemistry and Microbiology at UBC’s Okanagan Campus.
The presence of the bacteria can contribute to tumour growth, spread of cancer to other sites in the body, and resistance to chemotherapy.
With the help of the CMCF beamline at the Canadian Light Source (CLS), Wolthers and her colleagues determined that the new protein they identified enables the bacteria to take essential nutrients, such as iron, from our blood cells.
“Most of the iron in the body is tied up in a molecule called heme which is surrounded by a protein cage,” says Wolthers. “What we’ve discovered now is a new way for this bacterium to acquire essential nutrients from a very abundant source allowing it to grow very well in parts of the body that are free of oxygen.”
The discovery could eventually lead to the development of new drugs that specifically target the protein.
More information online
Buyers Guide - Major producers of analytical equipment who wish to introduce and sell their products to buyers in science and industry - Over 1,000 products and services that these companys man...
View all digital editions
Jan 17 2024 Birmingham, UK
Jan 24 2024 Tokyo, Japan
Jan 29 2024 Dubai, UAE
Jan 31 2024 Tokyo, Japan
Feb 03 2024 Boston, MA, USA