Ultrasound  adds new Dimension to Biofabrication

Scientists from the Universities of Bristol and Bath have found a way to coax microscopic particles and droplets into precise patterns by harnessing the power of sound in air. By using a new technique called sonolithography they were able to show that it's possible to create precise, pre-determined patterns on surfaces from aerosol droplets or particles, using computer-controlled ultrasound.

Dr Jenna Shapiro, Research Associate in the School of Cellular and Molecular Medicine at the University of Bristol and lead author of the article, said: "Sonolithography enables gentle, non-contact and rapid patterning of cells and biomaterials on surfaces. Tissue engineering can use biofabrication methods to build defined structures of cells and materials. We are adding a new technique to the biofabrication toolbox."

The researchers believe their work could revolutionise printing, improving the speed, cost, and precision of non-contact patterning techniques in air. Their work already shows the potential of sonolithography for biofabrication.

Professor Mike Fraser from the Department of Computer Science at the University of Bath, explained: "The power of ultrasound has already been shown to levitate small particles. We are excited to have hugely expanded the range of applications by patterning dense clouds of material in air at scale and being able to algorithmically control how the material settles into shapes."

Bruce Drinkwater, Professor of Ultrasonics in Bristol University's Department of Mechanical Engineering, added: "The objects we are manipulating are the size of water drops in clouds. It's incredibly exciting to be able to move such small things with such fine control. This could allow us to direct aerosol sprays with unheard of precision, with applications such as drug delivery or wound healing."

Beyond its applications in biomedicine, the team has shown the technique to be applicable to a variety of materials. Printed electronics is another area the team is keen to develop, with sonolithography being used to arrange conductive inks into circuits and components.

‘Sonolithography: in-air ultrasonic particulate and droplet manipulation for multi-scale surface patterning’ by Jenna M. Shapiro, Bruce W. Drinkwater, Adam W. Perriman, and Mike Fraser is published in Advanced Materials Technologies [open access]

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