High Sensitivity Diode Array Detector for LC Introduced

Agilent Technologies Inc have introduced the 1200 Infinity Series high dynamic range diode array detector for liquid chromatography. It delivers 30 times wider linear UV-range and up to 30 times higher sensitivity than previous detectors. That makes the 1200 Infinity Series detector ideal for analysing mixtures that contain widely different concentration levels.

Analysing such samples usually requires additional sample preparation (dilution/concentration) and a second injection, sometimes with recalibration. The new Agilent 1200 Infinity Series detector eliminates these time-consuming efforts, acquiring all sample information in a single run – significantly increasing productivity by reducing turnaround time.

The Agilent solution extends the upper linearity level from two to typically six absorbance units. This allows injection of three times more sample while also reducing detector noise by 10 times. The result is up to 30 times higher sensitivity for simultaneous analysis and quantification of main compounds and impurities.

“We are excited by the new 1200 Infinity Series HDR-DAD as it simplifies the quantitation across many LC  applications,” said Christian Gotenfels, Agilent Product Manager. “For example in pharmaceutical analysis, the Agilent solution facilitates quantitation of active pharmaceutical ingredients and respective impurities of fixed-dose  combinations in a single run.”

The technology in Agilent’s Max-Light flow cells enables the wider linear dynamic range. Optofluidic waveguides facilitate total internal reflection for superior light transmission. This delivers extremely low detector noise, regardless of the length of the optical path. By combining the signals from two diode array detectors with different path-length Max-Light flow cells, the linear range is expanded by a factor of 30.