• What's the Difference Between PSA and Membrane Nitrogen Generators?

Chromatography

What's the Difference Between PSA and Membrane Nitrogen Generators?

Jun 15 2022

All nitrogen gas generators are designed to produce pure, high-quality gas for laboratory applications. However, there are variations between models. Below, we explain the key differences between PSA and Membrane Separation nitrogen generators.

First, let’s take a look at how each type of generator produces nitrogen.

Membrane Separation generators

Membrane Separation gas generators use compressed air to produce high-quality nitrogen. Every device features a built-in separation membrane made up of thousands of hollow, permeable fibres. As compressed air passes through the membrane, ‘fast’ gases such as oxygen and CO2 travel through the fibres faster than nitrogen, which is a ‘slow’ gas. The purified nitrogen is captured and can then be used for laboratory applications.

Pressure Swing Adsorption (PSA) Generators

Like Membrane Separation generators, PSA systems generate lab-quality nitrogen using compressed air. A porous Carbon Molecular Sieve (CMS) is used to capture oxygen from compressed air and allow larger nitrogen molecules to filter through. To prevent the CMS from becoming soaked with oxygen molecules, PSA generators feature two columns. One continually separates gas while another is cleansed with ultra-pure nitrogen. This ensures operators have access to a reliable and constant stream of nitrogen.

PSA vs Membrane Separation technology

There are three main differences between PSA and Membrane Separation technology, explored in more detail below:

  • Purity

Purity is the main differentiator when it comes to PSA vs Membrane Separation technology. PSA generators are gold-standard and can produce nitrogen with purity levels as high as 99.9995%. This makes them the generator of choice for applications where purity is a priority. Nitrogen Separation Membrane generators also offer exceptional quality, though not as high as PSA systems. The devices can achieve purity levels of 99.5%.

  • Reliability

Membrane Separation gas generators are the simplest of the two technologies. Devices have very few moving parts which minimises the risk of failure. PSA generators produce exceptionally pure nitrogen though they rely on components such as valves, adsorption beds, buffer tanks, control panels and multiple columns. This means they generally require more maintenance.

  • Convenience

Both PSA and Membrane Separation gas generators are easy to operate and require very little training. In terms of size, Membrane Separation generators are usually more compact and desktop friendly. PSA generators tend to have a larger footprint due to the more sophisticated technology.  

From preserving highly sensitive active ingredients used in drug discovery labs to controlling environmental conditions in IVF incubators, nitrogen is used across a wide range of sectors and industries. Find out more about the benefits of nitrogen gas generators, as well as devices such as hydrogen gas generators, zero air generators and Total Organic Carbon (TOC) generators, in our complete guide, ‘Laboratory Generators - Everything You Need to Know’. Or check out 'Optimising Bioreactor Yields with Smart Sensors' for more on the latest laboratory developments.


Digital Edition

Lab Asia 29.6 Dec

December 2022

In This Edition Chromatography - Optimising Viral Vector Purification Strategies with Multimodal Chromatography - Key UHPLC Characteristics Required for High throughput LC-MS - New Low Volu...

View all digital editions

Events

Medlab Middle East

Feb 06 2023 Dubai, UAE

FILTECH

Feb 14 2023 Cologne, Germany

SmartLab Exchange

Feb 22 2023 Amsterdam, Netherlands

SLAS 2023

Feb 25 2023 San Diego, CA, USA

View all events