Durable reversed-phase column for high-pH and high temperature applications

GL Sciences introduces Inertsil Hybrid-C18, an advanced reversed-phase HPLC column that combines the robustness of hybrid silica technology with the reliability required for high-performance analytical workflows. Designed for laboratories that routinely handle basic compounds or operate under harsh mobile phase conditions, this column offers long-lasting durability and excellent chromatographic performance across a wide pH range.

Unlike conventional silica-based C18 columns, which can degrade under alkaline mobile phase conditions, Inertsil Hybrid-C18 maintains high efficiency and peak shape integrity even at pH levels up to 12. This makes it a powerful tool for LC-MS, peptide separations, pharmaceutical analyses, and other applications requiring chemical stability and reproducibility.

Key Features of Inertsil Hybrid-C18:

• Wide usable pH range: 1–12
• High pH mobile phase and high temp. condition resistance using hybrid silica particles
• Excellent peak shape for basic and polar compounds
• Improved column lifetime under high-pH conditions
• Suitable for LC-MS and UHPLC applications
• Available in 1.7 µm, 3.5 µm, and 5 µm particle sizes