Signal-to-Noise Spec Replaced with Instrument Detection Limit for Triple Quadrupole GC/MS

Agilent Technologies, Inc announced that it is replacing the signal-to-noise specification with a new instrument detection limit specification for its 7000B triple quadrupole gas chromatography/mass spectrometry system. “Twenty or even 10 years ago, signal-to-noise was a reasonable indicator of GC/MS performance,” said Terry Sheehan, PhD, Agilent GC/MS Marketing Manager, “But GC/MS/MS baseline noise for simple standards is often too low and too inconsistent to be meaningful. Selection of different baseline segments can change the signal-to-noise ratio by five or even tenfold. Our new specification, the instrument detection limit, is based on the system’s precision, and precision directly correlates with ion count – the real measure of MS sensitivity.” Agilent considers IDL a better measure of GC/MS/MS performance because it follows the guidelines of the International Union of Pure and Applied Chemistry, the United States Environmental Protection Agency and many other organisations. IDL calculates typical

performance from a series of automated injections for an accurate view of system performance. The well-established Student’s t-test is applied to eight consecutive injections of 100 fg OFN using a 99% confidence interval. Additionally, the IDL specification confirms the performance of every component in the GC/MS/MS system, from the autosampler through the detector. The IDL specification of the Agilent 7000B GC/MS/MS system in EI mode is 12 fg OFN.“Dividing the MS signal of OFN standards by a noise value approaching zero gives a signal-to-noise ratio in the thousands, but that has no correlation to the system’s true performance,” Sheehan said. “It is time for ultra-low noise MS systems to use statistical detection criteria that are similar to the statistics that MS operators use for their methods.”