• New Cryo-TEM to Help Accelerate Drug Discovery Research

Microscopy & Microtechniques

New Cryo-TEM to Help Accelerate Drug Discovery Research

Oct 05 2022

Cryo-electron microscope with enhanced throughput and high-resolution imaging capabilities

The Thermo Scientific Glacios 2 Cryo-Transmission Electron Microscope (Cryo-TEM) is a powerful microscope with new automation and high-resolution imaging capabilities designed to help cryo-electron microscopy (cryo-EM) researchers of varying experience levels accelerate structure-based drug discovery. This advanced, fast and cost-efficient method for drug design may enable customers to accelerate the pace of research for debilitating disorders like Alzheimer’s, Parkinson’s, and Huntington’s diseases, as well as research for cancer and gene mutations.

The Glacios 2 Cryo-TEM includes automation features designed to extend accessibility to a range of cryo-EM techniques, including single particle analysis, cryo-electron tomography (cryo-ET) and microcrystal electron diffraction (MicroED). Additional highlights include fringe-free imaging for the acquisition of more usable images per foil hole, increased throughput compared to other commercially available optical alignment solutions and a new enclosure and hardware improvements built to offer enhanced performance compared to prior models.

This next generation solution can generate <2 angstrom 3D reconstructions and produce images faster than its predecessor. These capabilities can help users of all experience levels increase productivity at a time when rapid innovation and emerging cryo-EM applications are placing increasing demands on expert microscopists.

“Using the Glacios 2 Cryo-TEM, we developed a workflow that enables us to determine structures of small, asymmetric complexes at high resolution and with high throughput,” said Basil Greber, principal investigator for The Greber Laboratory at the Institute of Cancer Research and beta user of the new Glacios 2 Cryo-TEM. “Uncovering such structures provides us with detailed insight into inhibitor binding and suggests a mechanism for target selectivity in cancer therapeutics that we are currently testing.”  

The new system also includes Thermo Scientific Smart EPU Software, which contains components needed for automated data acquisition, including microscope alignment and readiness assistance, plus an open API to allow for the development of solutions tailored to a user’s needs.

“As the demand for cryo-EM continues to surge, automated, high-throughput instruments are critical to advancing life science research around the world, especially in the fast-paced pharmaceutical and biotech industries,” said Trisha Rice, Vice President and General Manager of Life Sciences at Thermo Fisher Scientific. “The Glacios 2 Cryo-TEM meets these needs by delivering high-quality structures quickly, taking some of the pressures away from microscope operation and giving time back to the scientists to focus on their groundbreaking research.”

For pharma and biotech companies, the Glacios 2 Cryo-TEM offers high-throughput screening and imaging to enable the routine structure generation of druggable targets, including key targets of <120 kDA in size. For labs with growing demand for cryo-EM, the Glacios 2 solution helps increase accessibility to near atomic resolution structures, while improving ease-of-use and reproducibility across a variety of workflows.

Register for a webinar on 18 October about new Glacios 2 Cryo-TEM-enabled research with Basil Greber.

More information online


Digital Edition

Labmate UK & Ireland 49.2 - March 2024

March 2024

In This Edition Articles - Choosing the right LIMS for your lab: Four key considerations - Pay increases to continue but staff focus on security and training - Building a global culture of...

View all digital editions

Events

Making Pharmaceuticals

Mar 26 2024 Milan, Italy

FORUM LABO LYON

Mar 27 2024 Lyon, France

Microbiology Society Annual Conference 2024

Apr 08 2024 Edinburgh 2024

analytica 2024

Apr 09 2024 Munich, Germany

ChemBio Finland 2024

Apr 10 2024 Helsinki, Finland

View all events