Verdel Instruments – Total Correlation Mass Spectrometry (TOC-MS)

Best bench top innovation

TOC-MS is a novel technique for analysing complex samples which can reduce, or remove, the need for chromatography. Available as an upgrade kit for existing Q-ToF-MS systems, TOC-MS allows the entirety of a sample to be analysed simultaneously without any prior knowledge of the analytes. The output is a 3-dimensional ‘data-cube’ which provides a data-rich holistic view of your sample, complete with precursor-fragment association.

How it works:

Verdel’s unique upgrade kit allows the quadrupole in a Q-TOF spectrometer to operate as a linear ion trap. Trapped ion radii are manipulated with an encoding technique that uniquely pairs fragments with their respective precursors. This combined with high-resolution mass measurement (in the TOF) allows identification of all components in the sample simultaneously. Our bespoke software - ‘TOCulus’ - makes the data analysis simple, identifying all the precursor ions present, correlating their fragments and providing accurate mass data for both in a single report. TOC-MS provides a breakthrough technique for data independent acquisition (DIA), reduces the need for chromatographic separation and can provide unique insight into your samples that simply can’t be achieved with other techniques.

Highlights:

• Data-independent analysis with precursor - fragment association
• Data-rich 2D-MS for whole sample elucidation
• Low cost upgrade to existing Q-ToF hardware with small bench-top footprint
• No a priori knowledge of sample required
• Minimal sample preparation / separation required
• All MS/MS data in one experiment and one data file - which can be reanalysed for additional data in future, without the need to re-run the sample