SCIEX – ZenoTOF 7600+ system

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As the newest system to the ZenoTOF line, the ZenoTOF 7600+ system features the cutting-edge ZT Scan DIA strategy, leveraging the combination of the quadrupole dimension with the rich MS/MS data achievable from the Zeno trap. The system aims to address a research gap – simplifying the transition of protein biomarker candidates beyond the discovery stage.

“This new system combines the depth of DIA methods with the specificity of DDA and the precision of targeted approaches to precisely quantify entire proteomes. Our goal is to facilitate researchers in optimizing their clinical and translational research workflows, and ultimately enable them to accelerate advancements in the field of precision medicine,” said Jose Castro-Perez, Vice President, Product Management.

Key features of the ZenoTOF 7600+ system include:

• ZT Scan DIA, the latest evolution of data independent acquisition, making it the only system to encompass a multi-acquisition combination of DDA, DIA and targeted approaches within a single workflow. Results are achieving over 125% more quantifiable protein groups at sub-nanogram levels than conventional discrete-window DIA.
• Electron activated dissociation (EAD) offers tunable fragmentation of all molecule types, further extending analytical capabilities.
• Scanning speeds of up to 640 Hz make this the fastest SCIEX accurate mass system, increasing the scope for large quantitation panels.
• Exposing a new dimension of data by mapping the MS/MS scans with the scanning Q1 quadrupole dimension, to further increases confidence and accuracy for the differentiation of isomeric peptides and localize post-translational modifications (PTMs).