High-sensitivity system transforms mass quantitation in complex omics

SCIEX has launched the ZenoTOF 8600 system at ASMS 2025, offering a significant advance in accurate mass quantitation for researchers working across proteomics, metabolomics, and lipidomics. Combining high sensitivity with expanded software capabilities, the new platform enables scientists to confidently quantify thousands of molecular species from complex biological samples in short acquisition times.

The ZenoTOF 8600 builds on SCIEX’s decades of innovation in mass spectrometry, incorporating new hardware to boost ion generation and transmission. The OptiFlow Pro source, along with DJet and QJet ion guides, improves ion throughput and, when used with the Zeno trap, delivers up to tenfold greater sensitivity compared to the ZenoTOF 7600+. A new optical detector supports higher ion currents, while Mass Guard technology - originally introduced on the SCIEX 7500+ - reduces contamination and improves instrument uptime.

The system also debuts ZT Scan DIA 2.0, an upgraded data acquisition method that expands mass range coverage and enhances performance across all omics disciplines. According to Dr Nicola Zamboni, Principal Investigator at ETH Zurich, “We’re not just detecting more compounds - we’re identifying up to 40% more. ZT Scan DIA 2.0 gives us access to new layers of biological insight, particularly for lipids and complex natural products.”

To support the high data throughput of the ZenoTOF 8600, SCIEX OS 4.0 introduces faster, more automated workflows for efficient processing. The updated software ecosystem also supports third-party integration. New collaborations include MS-Dial, which now supports SCIEX raw data in multiple scan modes, enhancing small molecule identification via spectral deconvolution. In proteomics, SCIEX continues its partnership with Bioinformatics Solutions Inc, whose PEAKS Studio 13 provides expanded peptide and PTM identification, optimised for ZT Scan DIA, SWATH DIA, and DDA data.

“The ZenoTOF 8600 and its supporting tools are already making a real difference in omics research,” said Dr. Jose Castro-Perez, Vice President of Product Management at SCIEX. “We’re excited by the depth of insight our customers are starting to uncover.”

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