Chromatography

What Are the Different Methods of Insulin Delivery?

Dec 31 2017 Read 1984 Times

Currently, self-administered injections are the most popular method of delivering insulin to the body. This is usually done via syringes, insulin pens, jet injectors and insulin pumps. Now, diabetes patients could be set to enjoy a new era of blood sugar management.

With around 6% of the UK population currently living with diabetes, the breakthrough could literally chance millions of lives. The USA is also set to benefit, with over 9% of the population currently diagnosed with Type 1 or Type 2 diabetes.

Introducing a synthetic "smart gel"

Developed by a team of Japanese researchers from the Tokyo Medical and Dental University, the method involves implanting a synthetic "smart gel" under the skin. Unlike previous electronic-free insulin delivery systems that rely on glucose oxidase and sugar-binding lectins to sense glucose, the new method champions a protein-free, 100% synthetic approach.

A clever closed-loop system

The "smart gel" takes advantage of the sugar-responsive properties of boronic acid and delivers insulin in a single catheter. Once implanted the gel uses a closed-loop system to act as an artificial pancreas. When glucose levels are high the gel becomes permeable and releases doses of insulin into the body. Similarly, as glucose levels drop it develops a protective skin that stops insulin delivery. This empowers the body with the ability to control the glucose metabolism for up to three weeks. The method has already succeeded in delivering glucose-responsive insulin to diabetic mice, with the team hoping to proceed to human trials in 2018.

An economic and disposable solution

"Our “smart gel” technology could offer a user-friendly and remarkably economic (disposable) alternative to the current state of the art, thereby facilitating availability of effective insulin treatment not only to diabetic patients in developing countries but also to those patients who otherwise may not be strongly motivated, such as the elderly, infants, and patients in need of nursing care," reads an abstract published by the journal Science Advances.

Universities play a critical role in developing medical breakthroughs. For a closer look at the latest developments don't miss 'Analytical Method Development and Validation for the Identification of Spiraeoside Using RP-HPLC in Pharmaceutical Gel Formulation'. It spotlights the latest Reversed-Phase High Performance Liquid Chromatographic (RP-HPLC) method, and concludes that identification of spiraeoside is specific and selective according to validation studies.

Read comments0

Do you like or dislike what you have read? Why not post a comment to tell others / the manufacturer and our Editor what you think. To leave comments please complete the form below. Providing the content is approved, your comment will be on screen in less than 24 hours. Leaving comments on product information and articles can assist with future editorial and article content. Post questions, thoughts or simply whether you like the content.


Digital Edition

International Labmate Buyers Guide 2018

June 2018

In This Edition Articles - Choosing the Optimum Plasma Spectrochemistry Technique for Measuring Elemental Impurities in Pharmaceuticals - Monitoring Airborne Molecular Contamination in Indoo...

View all digital editions

Events

INTERPHEX JAPAN 2018

Jun 27 2018 Tokyo, Japan

PREP 2018

Jul 08 2018 Baltimore, MD, USA

AACC Annual Meeting & Clinical Lab Expo 2018

Jul 29 2018 Chicago, IL, USA

HPLC 2018

Jul 29 2018 Washington DC, USA

M&M 2018

Aug 05 2018 Baltimore, MD, USA

View all events