New Larger Diameter Core-Shell HPLC Prep Column Choice Enables Higher Loads for Pharmaceutical Lab-Scale Purification

Phenomenex Inc announces a new 30mm I.D. (internal diameter) Kinetex core-shell 5-micron column in Axia™ hardware for preparative HPLC and SFC in pharmaceutical lab-scale purification. Also offered in a 21.2mm I.D., the new 30mm column enables increased sample loading and throughput. With the addition of this larger diameter column, Phenomenex offers the only core-shell media line that can be used from analytical scale through scale-up to purification. The Phenomenex Axia preparative format delivers longer column lifetime, higher efficiencies, improved performance and high reproducibility, compared to conventionally packed columns for lab-scale preparative chromatography. 

“Our range of Kinetex core-shell particle size offerings, including 1.3-, 1.7-, 2.6- and 5-micron, enables exacting scale-up in pharmaceutical applications, eliminating extensive method rework,” explained J.T. Presley, Brand Manager for Phenomenex. “The 30mm columns are now available in C18, XB-C18, C8 and Phenyl-Hexyl phases, and we will be introducing more phases in the near future.”

5-micron is the largest particle in the Kinetex core-shell family and delivers better performance than 5-micron fully porous offerings, with no increase in backpressure. In fact, the 5-micron media provides 60 to 90% higher average efficiencies compared to the same size fully porous columns with little to no method development. 

The Phenomenex patented Axia packing and hardware technology, introduced in 2005, eliminates the drawbacks of traditional slurry packing, delivering uniform bed density and dramatic performance advances. 

Kinetex Core-Shell Technology in the Axia preparative format delivers a performance advantage to customers in pharmaceutical and natural products development, who can now use scalable core-shell solutions from analytical stage UHPLC or HPLC methods to purification.