UHPLC Front End System Perfect for LC/MS Analysis in Drug Detection Processes

Shimadzu has introduced the Nexera MP UHPLC as a Front End system for LC/MS. The Nexera MP is perfect for LC/MS analysis conducted in pharmacokinetics and synthesis stages in drug detection processes.The new SIL-30ACMP Multiplate Autosampler used in the Nexera MP is best suited for LC/MS analysis and has the industry-best micro-volume injection repeatability, the world’s highest injection speed and the lowest carryover. Combining the Nexera MP with Shimadzu’s LCMS-8030 Triple Quadrupole Mass Spectrometer or the LCMS-2020 Single Quadrupole Mass Spectrometer creates a system for quick analysis of multiple samples with high accuracy.

Pharmacokinetics and candidate compound synthesis stages in drug discovery processes need fast analysis of multiple samples using an LC/MS system with high throughput. Minimisation of carryover in samples is also important for enhancement of LC/MS analysis reliability, since mass spectrometers are becoming more and more sensitive. The synthesis stage demands a system where two or more users can share an instrument and measure samples

without delay, so that candidate compounds can be checked and identified quickly for more efficient analysis. This setup also reduces power consumption, thereby lessening the burden on the environment. Combined with high-performance accessories, the Nexera MP UHPLC Front End system achieves outstanding features: efficient sample preparation; multi-sample processing with the world’s fastest injection; industry-lowest level carryover;

two or more analysers share one system; and column oven setting to the MS position. The Nexera MP is controlled by Shimadzu’s LabSolutions software and major LC/MS workstations available from other companies.