Library Maintenance for the Smaller Pharma

An application note from Genevac describes how their Model DD-4X centrifugal evaporator has been used by a pharmaceutical company to address the sample integrity and physical storage problems associated with compound library maintenance.

Entitled ‘Library maintenance for the smaller pharma’ the application note details a high throughput process to produce compound libraries as dry films that have been validated for long-term storage. The authors describe how compounds were solubilised, reformatted from 96- to 384-well plates and then dried down using a Genevac DD-4X centrifugal evaporator for storage at room temperature. The high capacity of the Model DD-4X is shown to facilitate sample-safe evaporation of sixteen 384-well plates to dryness in only 25 minutes at 40◦C. The described dry film methodology reduces the time for compound preparation and produces enough assay ready sets of dry film plates for at least 10 screens. The Model DD-4X from Genevac is an affordable, highperformance centrifugal evaporator system designed to handle the wide range of sample types and formats encountered in pharmaceutical laboratories.