Putting More Drug Discovery Tools in Customers Belt

LGC Standards has launched a new absorption, distribution, metabolism and excretion (ADME) toxicology guide comprising a unique collection of labelled and unlabelled reagents and standards, as well as important biological model systems. The Tools for ADME/Tox guide provides reference to Food and Drug Administration (FDA) guidelines and has specifically been developed for preclinical drug discovery and development scientists working across the spectrum of ADME and toxicology preclinical drug discovery and research.

The guide’s quick reference tables provide details of key metabolising enzymes with relevant substrates, metabolites, inhibitors and inducers. These tables then link to an alphabetical product listing which enable researchers to easily locate the specific reference standards and reagents required for their assays. The listing includes FDA Drug Development and Drug interaction guidance listing substrates, inhibitors and inducers as either preferred or acceptable. A significant number of metabolite standards are also available both labelled and unlabelled, with each product format’s availability clearly indicated.

The guide comprises a collection of model systems commonly used in preclinical drug discovery research. The range includes fresh hepatocytes from a series of species, available the day after isolation and key immortalised cell lines such as Caco-2 (HTB-37™) and primary cells from ATCC®.