Automated Solutions for Molecular Pharmacology

The Leibniz-Institut für Molekulare Pharmakologie in Berlin, Germany, is using Tecan’s Freedom EVO® workstations for systematic high throughput screening of bioactive small molecule libraries, looking for potential research tools and targets for drug development. Dr Jens Peter von Kries, Head of the Institute’s Screening Unit, explained: “The Screening Unit has a small team of staff performing library screens of around 20,000 compounds a day, and this high throughput is partly thanks to the flexibility of our Freedom EVO workstations. Many of our projects use either high content screening with

automated microscopes or genome-wide RNA interference (RNAi) studies, and we have a Freedom EVO system configured for each of these methods, as well as a platform equipped with a REMP Small Size Store™ for management of the ChemBioNet screening library.”

“Each workstation has been collaboratively designed with the Tecan Integration Group (TIG) to create a robust system that is capable of high throughput analysis, giving consistent results even with long term use. The approval procedure is central to this process, with both factory and site acceptance tests to guarantee that the platform exactly matches our needs. Tecan is very willing to support us with development of the platforms as new technologies become available, and we enjoy a very good working relationship with the company’s automation engineers, receiving immediate expert support for all our

projects. Tecan has an exceptional culture of customer service, and our work here at the FMP undoubtedly benefits from this close partnership.”