• Can X-ray Ptychography be used in Smaller Laboratory Source Facilities?
    "The SMALL laboratory at the University of Sheffield being prepared for the ptychographic imaging experiment with the installation of the portable end station designed at I13-1 of Diamond Light Source and the SLcam hyperspectral detector from Ghent University." Credit: Dr Parnell, University of Sheffield.
  • "A reduced selection of the four-dimensional intensity data recorded during the experiment." Credit: Diamond Light Source Ltd.

News & Views

Can X-ray Ptychography be used in Smaller Laboratory Source Facilities?

May 12 2021

X-ray ptychography has recently opened up applications across physical and life sciences at large-scale synchrotron facilities such as the UK’s Diamond Light Source, by producing quantitative phase images with the highest possible spatial resolutions (10’s nm) – going well beyond the conventional limitations of the available X-ray optics. Now an international collaboration of scientists has demonstrated for the first time how the technique of high-resolution phase contrast diffraction imaging can be performed with small-scale laboratory sources.

The team from Diamond Light Source, Ghent University, University of Sheffield, and University College London conducted an experiment with a compact liquid metal-jet (LMJ) X-ray source. Laboratory X-ray sources have significantly lower levels of brilliance but currently provide the X-ray synchrotron user community with access to micro-CT, where they can gain a great deal of experience and produce preliminary data, at their home institutions. Until now, no such equivalent has existed for nano-scale imaging through coherent diffraction imaging and ptychography. The team’s paper(1) outlines such an experiment and the first proof of concept for far field X-ray ptychography performed using an X-ray laboratory source. 

Diamond science group leader, Paul Quinn said: “We have been leading developments in ptychography to open this technique to new science areas and communities. It builds on the work we’ve done over many years and longer term this approach in particular has real potential to provide higher resolution imaging to lab source facilities.” 

Lead author, Darren Batey, Beamline Scientist on the I13-1 Coherence Beamline at Diamond explained further: “The success of the project strongly depended on the experience and knowledge we collected over the years at the synchrotron. The result of our most recent work allows preliminary studies to be made at Universities, increasing the influx of interesting science to our facility. A lab source facility like the one we have demonstrated with our collaborators, will complement capabilities at Diamond and other sources.” 

“Given the worldwide effort toward developing compact light sources, this experimental breakthrough is timely and has the potential of being applied to a whole range of compact light source configurations. The work unlocks the analytical power of ptychography to the wider scientific community and will drive forward the development of advanced coherent diffraction imaging methods. The work with our collaborators ensures that we keep on top of new technology and developments which can enhance the efficiency of experiments at Synchrotron facilities.” 

The data were collected at the University of Sheffield Soft Matter AnalyticaL Laboratory (SMALL) with the portable ptychography end-station from I13-1 of Diamond Light Source and a hyperspectral detector from Ghent University. The X-ray source is an Excillum liquid gallium metal jet (LMJ), which has a brilliance of one order of magnitude higher than conventional microfocus sources.  

“The resolution achieved in this first experiment is comparable to other lab-based phase contrast techniques, such as in-line phase contrast and edge illumination. The experimental breakthrough achieved with a LMJ is a first step toward expanding X-ray ptychography to other bright compact light sources: from inverse Compton scattering, to laser-plasma based and compact storage rings,” Darren Batey added. 

(1)  Paper in Physical Review Letters : X-ray Ptychography with a Laboratory Source 

Authors:  Darren J. Batey,1 Frederic Van Assche,2 Sander Vanheule,2 Matthieu N. Boone,2 Andrew J. Parnell,3 Oleksandr O. Mykhaylyk,4 Christoph Rau,1 and Silvia Cipiccia1, 5

1 Diamond Light Source, Harwell Science and Innovation Campus, Fermi Avenue, Didcot, UK       

2 UGCT-RP, Department of Physics and Astronomy, Ghent University, Belgium                              

3 Department of Physics and Astronomy, University of Sheffield, Sheffield, UK

4 Soft Matter Analytical Laboratory, Department of Chemistry, University of Sheffield, Sheffield, UK

5 Department of Medical Physics and Biomedical Engineering, University College London.

Further information online

Digital Edition

International Labmate Buyers Guide 2022

June 2022

In This Edition Evaluation of Recovery of Basic Analytes Using a Mixed-Mode Strong Cation Exchange SPE Microplate by HPLC-MS The Benefits of SEC-MALLS in Biopharmaceutical Applications...

View all digital editions


ISSS 2022

Jun 28 2022 Ljubljana, Slovenia

AACC Annual Meeting & Clinical Lab Expo

Jul 24 2022 Chicago, IL, USA

ICMGP 2022

Jul 25 2022 Virtual event

ACS National Meeting & Expo, Fall 2022

Aug 21 2022 Chicago, IL, USA & Online


Aug 22 2022 Frankfurt, Germany

View all events