News & Views

New Style Optical Traps bring Step-Change to Future Research

Jan 15 2018 Read 281 Times

Researchers at Dundee University have come up with a new way of creating optical traps – tightly focused laser beams that can confine and manipulate microscopic objects such as cells, bacteria and strands of DNA - using holographic beam-shaping to deploy such traps for the first time through hair-thin optical fibres capable of penetrating safely through living tissues. The ultra narrow optical fibre will enable researchers to access hidden cavities or introduce traps deep inside living organisms without causing any major damage even to the most sensitive tissues.

The new class of multimode fibres developed by the team, which feature previously unattainable levels of light concentration necessary for stable confinement of micro objects, also enables the positioning of multiple laser traps with nanometre precision.

With a footprint being as small as 35 μm in diameter (about half the thickness of a human hair), the instrument can be used to demonstrate the manipulation of micro-objects within a turbid cavity inaccessible to bulk optics.

A paper* describing the study, which was conducted in collaboration with colleagues from Germany and the Czech Republic, was authored by Dundee scientists Ivo Jorge Oliveira Teixeira Leite, Sergey Nikolayevich Turtaev, Professor Sir Alfred Cuschieri and Professor Tomáš Čižmár.

“Just like the proton packs used by the Ghostbusters, optical traps confine and manipulate objects, only remotely from the complexity of living organisms,” said Professor Čižmár. “To the best of our knowledge, this work is the first demonstration of three-dimensional confinement and manipulation of micro-objects by light via an optical fibre, which opens the door to exciting exploitations of optical traps in-vivo.

“This represent a step-change for future research because the primary application of optical traps is the study of intracellular machineries, which are overactive in cancer, and for which a new generation of anti-cancer drugs are being developed. Now we can study these processes in the environment of complex living tissue and organisms rather than artificial conditions.”

Professor Cuschieri added, “While there are no immediate implications for health practice so far, there is significant potential for better understanding of mechanical actions of biological molecules. Thanks to optical tweezers, we now have a much better idea about functions of muscles at molecular level as well as genetic processes and their disruptions.

”Now we have the chance to access real depths of living organisms and, without affecting the processes of life, perform elaborate studies of mechano-chemistry at the single molecule level, all in its natural environment.”

For details and videos of the traps at work visit www.dundee.ac.uk

*Published in Nature Photonics

Read comments0

Do you like or dislike what you have read? Why not post a comment to tell others / the manufacturer and our Editor what you think. To leave comments please complete the form below. Providing the content is approved, your comment will be on screen in less than 24 hours. Leaving comments on product information and articles can assist with future editorial and article content. Post questions, thoughts or simply whether you like the content.


Digital Edition

Lab Asia March / April 2018

April 2018

In this issue... Chromatography - Biphenylpropyl Modified Silica - New Application Book Offers Expertise in GPC Analysis - Same Separation, Speedier Solution - Advanced Laboratory Manageme...

View all digital editions

Events

ASMS Conference

Jun 03 2018 San Diego, CA, USA

Drug Discovery Summit

Jun 06 2018 Berlin, Germany

ACHEMA 2018

Jun 11 2018 Frankfurt, Germany

View all events