Throughput Optimisation in Chromatography

Chronos version 2.0 from Axel Semrau GmbH & Co is the ideal master software for the efficient automation of complex sample preparation procedures using CTC PAL samplers.

Chronos optimises complex autosampler process sequences and reduces waiting times for all system components, GC(MS) or LC(MS) systems and autosamplers. This is enabled by the intelligent algorithm used by Chronos to organise parallel execution of several samples without any loss of precision or reproducibility. This replaces the usual serial processing of samples and represents an innovation, which increases significantly the efficiency of the laboratories.

Chronos enables very flexible and simple creation of the sample list. Through integration of Xcalibur and ChemStation Chronos links the sample list for the autosampler control with the data system list, so that the user only has to manage one sample list. This simplifies handling, saves time and avoids errors.

A graphic representation of the sample processing is created at the touch of a button. Multi-stage sample preparation procedures can be parallelised automatically by means of an integrated algorithm. A graphic representation illustrates the process sequence. Predefined tasks allow quick and flexible creation of methods.

The new version Chronos 2.0 offers a range of new functions: support for liner exchanger functionality for ATAS Linex systems; valco valves can be programmed via serial interfaces; management of several sample lists; external programs for evaluation can be called from the methods; reading in weight results from Mettler Toledo balances; support for SPME fibre exchangers; support for ITEX functions; and import of csv files from LIM systems.

Chronos is supplied as standard with ready-made modules for the usual analysis procedures; this includes headspace, liquid injection, SPME and other standardised methods. If required, the user can generate modules in Chronos adapted to their own needs. Xcalibur from Thermo Scientific and ChemStation from Agilent are integrated.