Comprehensive Analysis of Biomaterials

Researchers at the NMI (Natural and Medical Sciences Institute) of the University of Tübingen in Germany are using the Viscotek TDAmax GPC/SEC triple detection system with Omnisec software, both from Malvern Instruments, in their analysis of biomaterials.

Mixtures of different polymers and biopolymers are used in the production of the degradable biomaterials that are the foundation of modern carrier matrices for regenerative medicine. With such applications in human medicine, comprehensive GMP- and GLP- compliant quality control of such polymer blends is becoming increasingly important.

The chromatographic separation of different polymer components using SEC and subsequent triple detection provides an excellent opportunity to obtain a comprehensive picture of the molecular weight and

molecular size of different polymers in a single step.

The NMI conducts applied research and development at the interface of biotechnology and materials science. Core competencies are in the pharmaceutical and biotechnology, biomedical engineering, surface and interface technology areas. With strong interdisciplinary working groups, the NMI works with national and international projects in close collaboration with basic research groups, hospitals and companies. The implementation of new findings from science into commercially viable products or processes is the challenge that the NMI has managed successful for 25 years.

Thus, the NMI offers its customers an integrated service from joint research and development projects to internationally usable, pivotal trials for medical devices and medicines. A manufacturing license is planned

by mid-2010 for GMP-compliant testing in the production of biomaterials as components of advanced therapy medicinal products.