Multiple Detection GPC System

At the American Chemical Society (ACS) Fall 2010 National Meeting & Exposition Malvern Instruments exhibited the Viscotek TDAmax multiple detection gel permeation chromatography (GPC) system together with instruments from the Zetasizer particle characterisation family.

Applications for the Viscotek TDAmax Triple Detector Array (TDA) GPC system from Malvern Instruments have been extended through the inclusion of a new viscometer in the setup. The TDA maximises the productivity of GPC analysis by simultaneously measuring absolute molecular weight, molecular size and intrinsic viscosity. The new viscometer combines unrivalled sensitivity with an innovative 316

stainless steel transducer construction that offers excellent chemical resistance. It therefore provides the most precise intrinsic viscosity and structural information for an expanded range of biomolecules, natural and synthetic polymers.

The unique viscometer design uses digital inert transducer technology to give a faster, more sensitive response to viscosity changes than traditional transducers. Its 316 stainless steel construction means that there are now few limitations, in terms of salt content or pH, on the chromatographic conditions that can be used. The TDAmax enables protein scientists to determine the degree of oligomerisation, aggregation, conformation, and conjugation in protein samples. For polymer scientists it delivers information for sensitive product quality control and process optimization.

Malvern’s award-winning Zetasizer series includes systems that measure particle size, zeta potential and molecular weight. The novel measurement technology and patented optics built into Zetasizer Nano systems for example make them equally applicable to characterising high concentration colloids and nanoparticles of all types, through to measurement of dilute proteins and macromolecules in their

native state.