Differential refractometer enhances light scattering molecular weight determination

Chromatography

Differential refractometer enhances light scattering molecular weight determination

06 Mar, 2025

Testa Analytical has introduced a new Differential Refractometer that significantly improves the accuracy of dn/dc determination for light scattering molecular weight analysis. A precise dn/dc value is crucial for accurate molecular weight measurements of biopolymers and polymers using light scattering techniques.

Utilising decades of expertise in Gel Permeation Chromatography (GPC) and Light Scattering, Testa Analytical has developed a highly effective and user-friendly differential refractometer accessory. This device delivers outstanding performance, ensuring reliable results with minimal effort.

The Differential Refractometer provides rapid and precise determination of the specific refractive index increment (dn/dc) for dissolved samples, offering high accuracy in just minutes. It is versatile, with no solvent restrictions and an extensive range of measurement temperatures, making it an indispensable tool for any light scattering laboratory. Additionally, the system offers multiple wavelength options, allowing seamless integration with the laser wavelength of light scattering instruments for consistent and reproducible results.

Operated via intuitive Windows™-based software, the device also facilitates the accurate determination of sample concentration for those with known dn/dc values.

Designed for efficiency, the instrument ensures complete sample recovery without dilution or contamination. Samples measured for dn/dc can be directly used in Light Scattering analysis, streamlining the process and minimising preparation time and potential errors.

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