Highest Performing UPLC Ever Engineered

Waters Corporation introduced the new Waters® ACQUITY UPLC® I-Class System, the highest performing UPLC® system ever engineered taking UltraPerformance LC® separations technology to the next level. For scientists challenged by the most difficult separations, the ACQUITY UPLC I-Class features the lowest system dispersion and lowest carryover in the industry today. Low dispersion maximises peak capacity thereby advancing chromatographic separations and optimising the performance of any mass spectrometer.

Keeping pace with today’s most advanced laboratories, the ACQUITY UPLC I-Class System excels when analysing complex, sample-limited compounds. Sample-limited compounds include high potency medications, trace levels

of food or water contamination, and (advanced) sophisticated biotherapeutics. These samples can represent complex separation challenges requiring an LC system that can maximise the benefits of sub-two-micron for faster

throughput and optimised MS performance.

While there are many innovations built into the new ACQUITY UPLC I-Class, minimal system volume is a new key feature. Reduced system volume significantly decreases dispersion rates for reproducibly higher resolution and superior peak capacity. Reduced dispersion and small peak volumes extend the sensitivity of any mass spectrometer. Additionally, low dispersion footprint allows users to reduce their separation cycle times without impact to the separation as resolution is maintained even for ballistic gradients lasting less than one minute. Also importantly, new design and materials dramatically reduce sample carryover effects, thus increasing user confidence in results.

The ACQUITY UPLC I-Class also features class leading flexibility and precise sampling capabilities. Depending on application needs, users can choose either the highest precision and lowest dispersion fixed-loop Sample

Manager, or the world’s first low dispersion variable volume Sample Manager with a flow-through needle design, which delivers high-precision injections, excellent sample recovery, and lowest sample carryover optimising the performance for even the most sensitive mass detectors.